Abstract

Aim: The aim of the study is to evaluate the effect of coticosteroids on serum p-selectin and TNF-alpha levels in septic rats so as to evaluate the therapeutic efficiency of corticosteroids on sepsis. Methods: This experimental study included 50 male Spraque Dawley rats. Rats were divided to 5 groups (control, sham. prednisolone treated, septic and septic plus prednisolone treated). After surgical perforation of intestine to build up a sepsis model, serum levels of p-selectin and TNF-alpha vuere assesed on 3rd and 6th hours. Statistical analysis was performed by using Mann Whitney U test. Results: In all septic groups, p-selectin and TNF-alpha levels were found significantly higher than those in control group. Af ter corticosteroid treatment on the septic rats, both p-selectin and TNF-alpha levels were significantly decreased. Conclusion: It is concluded that early corticosteroid treatment can reduce the levels of P-selectin and TNF-a in septic rats.Therefore, it is an efficient therapeutic agent in sepsis.