Abstract

INTRODUCTION

It was aimed in this study to evaluate the effect of pegylated interferon alfa 2a/2b and ribavirin - the agents used in chronic hepatitis C - on triglyceride index and metabolic factors.

METHODS

A total of 165 chronic hepatitis C patients applying to Katip celebi University Ataturk Research and Training Hospital, Department of Gastroenterology between 01.01.2005 - 01.01.2012 with ages ranging from 20 to 75 years having serum uric acid and HCV-RNA levels (0, 12, 24, 48 and 72 weeks) levels available were included in the study. These parameters were assesed according to the groups based on response to therapy (sustained virologic response - SVR, relapse and non responders).

RESULTS

Of the 165 patients SVR was achieved in 91 but 74 non SVR. HCV-RNA levels in patients without permanent viral response were higher than those with permanent viral response.In univariate analyzes, a significant relationship was found between age, 72 hours HOMA score, platelet count and log 10 HCV-RNA in patients with and without permanent viral response.

DISCUSSION AND CONCLUSION

There is a significant correlation between HOMA score and TyG index in patients with hepatitis C according to my study. No relationship was found between the TyG index levels and the treatment response. There is a need for prospective studies investigating the safety of the TyG index in hepatitis C patients.