Abstract

INTRODUCTION

Antibodies against HLA class I and II antigens are important in kidney transplantations because they cause rejections. Not only antibodies against HLA antigens but also those against non-HLA antigenic system play a role in antibody mediated rejections. In this study it was aimed to detect HLA-and non-HLA antibodies in individuals that experienced rejection attack.

METHODS

Thirteen patients, who clinically experienced rejection episodes according to the biochemical test results after transplantation, were tested by lymphocyte crossmatch (by using the lymphocytes of their living related donors) and non-HLA specific anti-endothelial crossmatch methods.

RESULTS

Antibodies specific for Tie-2 receptor positive cells were not detected. The results of XM-ONE cross-match and flow crossmatch tests were found to be compatible with each other.

DISCUSSION AND CONCLUSION

In conclusion, it was considered that immunosuppressive treatment protocols and surgical complications play important role in rejection attacks. Further studies can contributed to determination of graft survival.