Abstract
A 39 year-old woman was admitted with anorexia, difficulty in swallowing, diarrhea and weight loss. Although the patient was diagnosed with HIV infection 14 years ago,her first admission to hospital was in 2008 and she was not taking her drugs regularly. The patient was diagnosed with CMV infection and candida oesophagitis. Resistance to many of the antiretroviral agents was detected. With the change of anti-retroviral treatment and treating of the opportunistic infections her symptoms were regressed. Drug resistance and opportunistic infections can ocur in HIV-infected patients who do not use their drugs regularly. Therefore, close monitoring is important for maintaining regular therapy and prevention of bacterial and mycotic complications.